Nordic Autophagy Network
Autophagy is a self-cleaning process responsible for elimination of damaged cellular components. Autophagy is also a renovation mechanism that is able to degrade pathogens and toxic compounds. In addition, autophagy is necessary for cell survival during conditions of nutrient deprivation and it has been found to have roles in tumour suppression and neuroprotection.
Defective autophagy has been linked to several diseases and is therefore an obvious candidate for therapeutic interventions. In order to identify suitable therapeutic targets a detailed understanding of the molecular machineries involved in autophagy and its regulations is required. An approach combining state-of-the-art genomics and proteomics with cell biological models and clinically relevant systems is vital.
Through the work of this researcher network, the Nordic research on autophagy shall be strengthened and synergisms between the different research groups can create a fertile ground for the training of next generation researchers.