Nordic Chemical Biology Consortium

We propose to expand the Nordic collaborations by forming a Nordic Academic Compound Collection, linking to existing national and European networks. The plan is to accumulate compounds prepared and collected by Nordic chemists and make them available to Nordic scientists.

Small bioactive compounds, “tool compounds”, serve as proof-of-principle molecules and intermediates e.g. in the development of many commercial products such as medicines or crop protective agents. In addition, their use complements other genetic and molecular biology methods enabling scientists to gain novel insight into the molecular mechanisms of biological processes. To identify effective bioactive compounds, large compound collections (containing tens of thousands of compounds or more) need to be screened. This kind of high throughput screening and the development of the hits to tool compounds require enormous resources unavailable to many researchers; high tech facilities, investment and experienced personnel. Scientists and institutions in the Nordic countries have established screening facilities that serve the scientific community and participate in education on all levels. To make efficient use of these existing infrastructures and to develop capacities to serve research that is aimed to address grand challenges, coordination on both national and international level is critical. In this proposal we focus on two areas: formation of 1) a Nordic Academic Compound Collection (NACC) and 2) a staff exchange program. 

We propose to expand the Nordic collaborations by forming a Nordic Academic Compound Collection, linking to existing national and European networks. The plan is to accumulate compounds prepared and collected by Nordic chemists and make them available to Nordic scientists. Biologists will benefit from the opportunity to discover novel bioactive small molecules from a larger and more diverse set of molecules (and therefore bioactivities) than is available in their own countries. Organic and medicinal chemists will have compounds screened in a large number of assays by users of the screening infrastructures. Validated hit compounds will then lead to new collaborations between chemists and biologists. We will use the NordForsk funding for workshops for planning and building up the NACC.

We also aim at spreading Nordic expertise by organising a research exchange program. This program will provide Nordic researchers excellent opportunities for education and skill development at sites, which have expertise and technologies not available at their home institution. The staff exchange program will strengthen interactions between infrastructures and train staff to make optimal use of Nordic expertise and resources.

Fakta om prosjektet

Project number: 70469

Prosjektleder

Mikael Elofsson, Umeå University

Varighet
2014-2016